The second round matches took place on Saturday, May 10, at the clay-court ATP Masters 1000 tournament in Rome.
Jakub Mensik (Czech Republic, 20) – Matteo Gigante (Italy, WC) – 7/6(4), 7/5
Jesper De Jong (Netherlands, LL) – Alejandro Davidovich Fokina (Spain, 25) – 6/0, 6/2
Hubert Hurkacz (Poland, 30) – Pedro Martinez (Spain) – 6/1, 7/5
Sebastian Korda (USA, 22) – Aleksandar Vukic (Australia) – 6/3, 6/4
Tomas Machac (Czech Republic, 19) – Learner Tien (USA) – 6/4, 6/4
Sebastian Ofner (Austria, Q) – Frances Tiafoe (USA, 15) – 6/2, 6/7(2), 6/3
Matteo Berrettini (Italy, 29) – Jacob Fearnley (Great Britain) – 6/4, 7/6(0)
Hugo Dellien (Bolivia) – Thiago Seyboth Wild (Brazil) – 4/6, 6/3, 6/4
